Notably, UBQLN2-positive aggregates are not restricted to genetically linked ALS cases—they are also frequently found in sALS and in ALS cases associated with C9ORF72 repeat expansions, which are typically characterized by TDP-43 inclusions (Brettschneider et al., 2012). The gene discussed is UBQLN2; the disease is amyotrophic lateral sclerosis.