The signature histopathologic feature of ALS is the accumulation of misfolded, cytosolic TDP-43 (43 kDa TAR DNA-binding protein) which is seen in virtually all instances of ALS except those caused by mutations in superoxide dismutase 1 (SOD1) or fused in sarcoma (FUS) (Babazadeh et al., 2023; Neumann et al., 2006). Here, TARDBP is linked to amyotrophic lateral sclerosis.