Other proteins enriched in UBQLN24XALS IPs included BTBD2, which encodes a Ub E3 ligase involved in cytoskeletal dynamics and Top1-mediated chromatin relaxation (Xu et al., 2003; Xu et al., 2002; Bagattin et al., 2024), and phospholipase B D2 (PLBD2), a lysosomal phospholipase that has been implicated in the lysosomal storage disorder, Batten’s Disease (Nyame et al., 2024). This evidence concerns the gene PLBD2 and lysosomal storage disease.