Notably, multiple proteins associated with ALS, such as TDP-43, FUS, heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), and heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1), are recruited to SGs, and mutations in these proteins often result in aberrant SG dynamics (Wolozin and Ivanov, 2019; Xue et al., 2020). This evidence concerns the gene HNRNPA2B1 and amyotrophic lateral sclerosis.