TARDBP and amyotrophic lateral sclerosis: Abnormalities in RNA metabolism appear to be a major mechanistic contributor to ALS and are linked to the most common pathological characteristic, which is the cytoplasmic mislocalization and aggregation of TAR DNA binding protein (TDP-43) that occurs in about 97% of all cases (Ling et al., 2013; Neumann et al., 2006).