Recent studies have expanded its relevance to neurodegenerative disorders, showing that TPP1 contributes to amyloid-β (Aβ) clearance in Alzheimer’s disease by cleaving fibrillar Aβ at multiple sites, including within the β-sheet region, thereby promoting structural destabilization and enhanced degradation [73]. Here, TPP1 is linked to early-onset autosomal dominant Alzheimer disease.