The association between the dietary OBS and DKD was statistically significant (all p < 0.05), with ORs (95% CIs) of 0.90 (0.83–0.98) when dietary OBS was analyzed as a continuous variable and with ORs (95% CIs) for the upper quartile of the dietary OBSs of 0.10 (0.03–0.29), 0.16 (0.04–0.61), and 0.18 (0.04–0.73) compared to the lowest quartile, respectively, when the dietary OBS is a categorical variable after adjusting for age, sex, ethnicity, HGB, ACR, SBP, DBP, HbA1c, ALT, AST, eGFR, TC, smoking status, drinking status, CHF, CVD, and hypoglycemic drug use. The gene discussed is CYGB; the disease is diabetic kidney disease.