The association between oxidative stress and DKD is complex and significant, driven by hyperglycemia-induced overproduction of mitochondrial ROS, which activates multiple pathological pathways, including Protein Kinases C (PKC), Advanced Glycation End-products (AGEs), and hexosamine biosynthetic flux, ultimately leading to renal inflammation, fibrosis, and apoptosis (32). Here, PRRT2 is linked to Hyperglycemia.