Critically, animal models have validated kallistatin's protective role in sepsis-associated acute lung injury through suppressing intracellular reactive oxygen species (ROS) generation and NF-κB activation, and stimulating tyrosine-kinase-protein kinase C-extracellular signal-regulated kinase (ERK) signaling, thereby alleviating inflammatory responses (4, 90). Here, SERPINA4 is linked to Sepsis.