In contrast, the desmoplakin (DSP) gene, encoding the primary component of desmosomes, has been predominantly associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) and dilated cardiomyopathy (DCM) (3, 4), with limited evidence supporting its role in HCM pathogenesis. This evidence concerns the gene DSP and arrhythmogenic right ventricular cardiomyopathy.