The mislocalization and aggregation of TDP-43 is not only a frequent co-morbidity in AD but is also the defining pathological hallmark of other major dementias, including Frontotemporal Dementia (FTD) and the more recently characterized Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) (Josephs et al., 2014; Nelson et al., 2019). Here, TARDBP is linked to frontotemporal dementia.