ANGPTL3 and diabetes mellitus: In the Ludwigshafen Risk and Cardiovascular Health study and the German epidemiological trial on ankle–brachial index (ABI), ANGPTL3/8 was not associated with cardiovascular mortality; in contrast, free ANGPTL3 was positively associated with cardiovascular mortality in ABI, and the C-terminal fragment of ANGPTL4 correlated with inflammation, diabetes prevalence, and cardiovascular mortality (72).