CASP3 and type 2 diabetes mellitus: The results of Western blotting assay (Figures 7A–C) showed that compared with the control group, the protein expression levels of Bax and Caspase-3 in the gastrocnemius muscle tissue of T2DM rats were significantly increased, and the difference was statistically significant (p < 0.05); compared with the control group, the mRNA levels of Bax and Caspase-3 in the gastrocnemius muscle tissue of T2DM rats were significantly increased, and the difference was statistically significant (P < 0.001) (Figures 7D, E).