Furthermore, evidence suggests that serum urate enhances the release of proinflammatory cytokines through upregulation of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9), consequently activating the NF-κB/MAPK signaling cascade and leading to myocardial hypertrophy and fibrosis (17). This evidence concerns the gene SLC22A12 and cardiac hypertrophy.