With respect to biological mechanisms underlying a potential association between higher aldosterone and adverse HT and CHD outcomes, important independent biological CHD risk factors that underly the process of atherosclerosis and thrombosis include markers of inflammation and hyperlipidemia, such as high levels of C-reactive protein (CRP) or low-density lipoprotein (LDL) (e.g (32). The gene discussed is CRP; the disease is coronary artery disorder.