Kaplan-Meier survival analysis revealed median survival times of 39, 43.5, 47, 50, and >58 days for PBS, M1-EXOs, iM1-EXOs, M1-EXOs-PAN, and iM1-EXOs-PAN treatment groups, respectively (Fig. 7F). This evidence concerns the gene ADA2 and polyarteritis nodosa.