For example, in a rat model of transient global cerebral ischemia, CBD was effective in increasing brain-derived neurotrophic factor (BDNF) levels and in reducing ischemia-induced memory deficits, hippocampal CA1 neurodegeneration and deleterious changes in dendritic spine number and the length of dendritic arborization (Meyer et al., 2021). Here, BDNF is linked to ischemia.