NLRP3 inflammasome is a key regulator of inflammation in this cancer for enhance tumor cell growth, survival, migration, and invasion by regulating autophagy, mitochondrial metabolism, EMT (Xu Z. et al., 2021), angiogenesis, immune evasion, and metastasis (Sharma and Kanneganti, 2021). Here, NLRP3 is linked to neoplasm.