NLRP3 and cancer: In particular, the increased expression of NLRP3 in human Breast Cancer Associated Fibroblasts (CAFs) is a precursor to cancer progression and metastasis through secretion of IL-1β (Saponaro et al., 2021) which stimulates angiogenesis, immune evasion, epithelial-mesenchymal transition (EMT), and stemness (Saponaro et al., 2021).