For example, NLRP3 and IL-1β overexpression in tumor-associated macrophages (TAMs), was associated with survival, lymph node invasion, and metastasis in patients with HER2+ breast cancer (Weichand et al., 2017), and interestingly, in murine invasive breast cancer models, the absence of a functional NLRP3 inhibited tumor growth (Guey et al., 2020). This evidence concerns the gene ERBB2 and neoplasm.