According to various studies, NLRP3 expression may influence the B-T cells compositional ratio and macrophages in the immunological microenvironment of Skin Cutaneous Melanoma (SKCM) tumor tissue, therefore indirectly modulating the expression of programmed death-ligand 1 (PD-L1) on melanoma cells, which suppresses the activation and function of CD8+ T cells, influencing tumor progression. This evidence concerns the gene CD8A and neoplasm.