In this context, the NLRP3 inflammasome’s overexpression has been linked to a range of malignancies (Wang et al., 2018) and its divergent role in different tissue tumor types, such as bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), rectum adenocarcinoma (READ), kidney renal clear cell carcinoma (KIRC), and stomach adenocarcinoma (STAD) in which are both downregulated and upregulated (Wang et al., 2022), has been extensively discussed. Here, NLRP3 is linked to bladder transitional cell carcinoma.