In this context, since the expression of NLRP3 protein and other factors of this pathway is not well characterized in OSCC and Potentially Malignant Oral Disorders (PMODs), a lot of studies aim to explore NLRP3 inflammasome/IL-1β signaling pathway composed with the inflammatory microenvironment and tumor immunity, their role in OSCC and their potentially association with pathological parameters including tumor size, depth of invasion (DOI), pTNM stage, and perineural and lympho vascular invasion. This evidence concerns the gene NLRP3 and neoplasm.