miR-22-3p exerts protective effects in coronary artery disease by downregulating NLRP3 in injured endothelial cells (Huang W. Q. et al., 2017) and suppresses cell proliferation, migration, and invasion in OSCC by targeting NLRP3 (Feng et al., 2018). The gene discussed is NLRP3; the disease is coronary artery disorder.