Since the identification of miR-223-3p as the first miRNA to directly target NLRP3, several miRNAs, including miR-22-3p, miR-7-5p, and miR-30e-5p, have been shown to suppress NLRP3 activity in various pathological settings, including oral squamous cell carcinoma, where miR-22-3p downregulates NLRP3, inhibiting its proliferation, migration, and invasion. This evidence concerns the gene NLRP3 and oral cavity squamous cell carcinoma.