Over-activation of NF-κB, signal transducer and activator of transcription (STAT) signaling, and hypoxia-inducible factor-1α (HIF-1α), a crucial transcription factor, is more significant in bladder cancer by upregulating the expression of NLRP3 and pro-IL-1β and the activation of pyroptosis (Jiang et al., 2020), resulting in an aberrant rise in inflammatory cytokines and immune cell over-response, encouraging cancer (Xu G. et al., 2021). This evidence concerns the gene IL1B and cancer.