Across the seven algorithms, several genes—including P2RX7, PTPN1, CD38, KDM3A, CAT, NOS3, MERTK, and AKT2—repeatedly appeared among the top-ranked features, suggesting robust and model-independent contributions to the T2DM–control separation (Figure 4D). The gene discussed is NOS3; the disease is type 2 diabetes mellitus.