MMP9 and colorectal carcinoma: Another class of drugs that scored highly in this case was the statins via targeting of MMP9, MMP14 and ICAM1 overexpression with Z-score = 3.4; CRC = 0.94, Z-score = 2.8; CRC = 0.85 and Z-score = 1.4; CRC = 0.87 respectively, for the stain pravastatin.