Studies indicate that CD8+ T cells activated by immunotherapy can downregulate the expression of XCT subunits SLC7A11 and SLC3A2 on tumor cell membranes through the secretion of interferon‐gamma (IFN‐γ), enhancing intracellular lipid peroxidation and leading to tumor cell ferroptosis [78]. The gene discussed is SLC3A2; the disease is neoplasm.