Furthermore, KRAS mutations – a driver gene more prevalent in pancreatic ductal adenocarcinoma – are also observed in some PNEC cases, potentially promoting rapid growth and drug resistance.[38] Conversely, MEN1 mutations, common in well-differentiated pancreatic neuroendocrine tumors, are extremely rare in PNEC, highlighting the distinct genetic origins of these 2 tumor entities.[38] Our prognostic model, developed based on age, differentiation grade, and metastatic patterns, would significantly enhance predictive accuracy if integrated with such molecular data. This evidence concerns the gene KRAS and pancreatic ductal adenocarcinoma.