This is consistent with the view that STXBP1-encephalopathy is a primary neurodevelopmental disorder rather than a pure epileptic encephalopathy.[23] Therefore, the treatment of STXBP1-encephalopathy should include not only antiepileptic treatment but also early and continuous neurorehabilitation training to improve the quality of life of patients. Here, STXBP1 is linked to neurodevelopmental disorder.