In 2017, the International League Against Epilepsy (ILAE) identified a series of manifestations caused by this gene mutation, such as epilepsy and developmental delay, as STXBP1-encephalopathy.[8] We conducted a retrospective analysis of genetic test results and clinical characteristics from 19 cases of STXBP1-encephalopathy. Here, STXBP1 is linked to epilepsy.