This is consistent with the view that STXBP1-encephalopathy is a primary neurodevelopmental disorder rather than a pure epileptic encephalopathy.[23] Therefore, the treatment of STXBP1-encephalopathy should include not only antiepileptic treatment but also early and continuous neurorehabilitation training to improve the quality of life of patients. This evidence concerns the gene STXBP1 and Epileptic encephalopathy.