STXBP1 and Global developmental delay: STXBP1-encephalopathy is a severe neurodevelopmental disorder caused by heterozygous pathogenic variants in the STXBP1 gene, characterized by early-onset refractory epilepsy and severe developmental delay.[10] This study systematically analyzed the clinical and genetic characteristics of 19 Chinese children with STXBP1-encephalopathy, identified 7 novel pathogenic variants, and confirmed the good efficacy of LEV, which provides important clinical and genetic data for the diagnosis and treatment of this disease in Chinese populations.