STXBP1 and Encephalopathy: Consistent with previous studies,[11,12] STXBP1-encephalopathy in our cohort showed obvious early-onset characteristics: 78.9% of cases had onset within the neonatal period, and the earliest onset was 3 hours after birth, which is earlier than the median onset age (6 weeks) reported in European and American populations.[13] This suggests that STXBP1-encephalopathy may have an earlier onset in Chinese children, which is of great significance for early clinical suspicion and diagnosis.