It may induce chronic inflammation via the LPS–TLR4/NF-κB signaling pathway, thereby impairing insulin signaling and ovarian function.[29] Additionally, Parabacteroides may contribute to PCOS related metabolic abnormalities by regulating bile acid metabolism through the FXR/TGR5 signaling pathway. The gene discussed is NR1H4; the disease is polycystic ovary syndrome.