BNIP3 and myocardial infarction: Ratul Datta Chaudhuri discovered novel crosstalk between HIF1A and NFκB pathways, which influences cardiomyocyte apoptosis by regulating bnip3 and ho-1 expression during myocardial infarction.[37] Moreover HIF1A, activated under hypoxic conditions, regulates the expression of genes related to the hypoxic response.