CLPB and Infertility: However, the clinical presentation of CLPB mutations can be variable; while not all patients show the full spectrum of features, neutropenia is frequently observed, particularly in those carrying heterozygous variants.[9] More recent studies have further noted premature ovarian failure and infertility in patients who survived beyond puberty.[10] These findings suggest that CLPB variants exert phenotypes effects that differ depending on their genomic location and dosage.[11]