The results revealed a predominance of tumor-related GnRH, Chemokine, ErbB, cAMP, and PPAR signaling pathways in the high-risk group; in the low-risk group, the GSEA showed enrichment for basal cell carcinoma, chemical carcinogenesis-DNA adducts, Hippo signaling pathway, Wnt signaling pathway, and breast cancer among all genes (see Supplementary Material 1, Supplemental Digital Content, https://links.lww.com/MD/R148). The gene discussed is GNRH1; the disease is breast carcinoma.