To date, more than 110 mutations in the LAMP2 gene have been identified, and the type of mutation correlates with the severity of the phenotype, with mutations in exons 1 to 8 being clinically severely manifested.[14] Previously reported LAMP2 intronic mutations cause DD via disrupted pre-mRNA splicing, and the resulting phenotypes depend on the level of residual LAMP2 protein function. The gene discussed is LAMP2; the disease is dentin dysplasia.