HLA-DRB1 and breast cancer: By studying the association between HLA-DRB1 and BC, it is helpful for early diagnosis, early treatment and prognosis of BC.[56] The analysis of 1182 immune-related genes showed that HLA-DRA was inversely related to the recurrence of ER-BC, and the expression characteristics of HLA-DRA had a higher prognosis for ER-BC and TNBC.[63]