In addition, the expression of ESR1 mutation is beneficial to the unique transcription profile of tumor progression, indicating that the selected ESR1 mutation may affect metastasis.[70] Transcriptional analysis from this study[70] and other study[71] shows that ESR1 mutation promotes the up-regulation of Hallmark cancer pathway, including estrogen response, p53 pathway and MTORC1 signal transduction, which indicates the role of mutant ER in promoting ET drug resistance and metastatic phenotype. This evidence concerns the gene TP53 and cancer.