Furthermore, those with mutations in the JAK2 V617F gene exhibited a heightened risk of cardiovascular events.[1] In patients with ET, ST-segment elevation myocardial infarction (STEMI) as the initial presentation is extremely rare, and the occurrence of concurrent occult sepsis is exceptionally uncommon.Cases of ET initially presenting with concurrent STEMI and occult sepsis are extremely uncommon, with only scattered reports of ET-related single complications (either STEMI or sepsis) in existing literature. The gene discussed is JAK2; the disease is Sepsis.