GLA and lysosomal storage disease: Fabry disease (FD; OMIM 301,500) is a lysosomal storage disease caused by pathogenic variants in the GLA gene which result in a deficiency of the enzyme alpha-galactosidase A (α-gal A; EC 3.2.1.22), causing a build-up of glycosphingolipids such as globotriaosylceramide (GL3) [1].