DSG3 and pemphigus vulgaris: Pemphigus vulgaris, caused by B cells reactive to desmoglein-3, serves as a model for chimeric autoantibody receptor (CAAR)-T therapy: Dsg3-CAAR-T cells selectively target and destroy B cells with anti-Dsg3 BCRs through granzyme/perforin mechanisms, while sparing most of the polyclonal humoral immune repertoire [372, 373].