VWF and von Willebrand disease (hereditary or acquired): Based on the allele frequencies of 321 previously reported VWF pathogenic variants identified in the gnomAD population, the estimated worldwide prevalence of VWD per 1,000 individuals was 10.6 for type 1, 1.3 for type 2A, 1.7 for type 2B, and 1.5 for type 2 M.