SERPING1 and chronic obstructive pulmonary disease: For example, SERPING1 expression is significantly reduced in the peripheral serum of patients with lung adenocarcinoma (LUAD), and experimental studies have confirmed its role in suppressing LUAD progression via the mTOR pathway.23 Additionally, SERPING1 alleviates bleomycin-induced lung injury.24 Despite MR studies reporting associations between SERPING1 and pulmonary function,25 the prognostic significance and mechanistic role of SERPING1 in COPD remain unclear.