Recent advances in proteome- and transcriptome-wide MR (pQTL-/eQTL-MR) have further enabled the integration of genetic variants with protein or RNA expression data, thereby offering deeper insights into the underlying molecular mechanisms of complex diseases.10 For example, proteome-wide MR (pQTL-MR) has successfully identified drug targets, such as IL-6R, for sepsis and sepsis-related mortality,11 demonstrating its potential to bridge genetic associations with therapeutic discovery. This evidence concerns the gene IL6R and Sepsis.