NFATC1 and rheumatoid arthritis: For example, Takegahara et al.12 provided an updated overview of osteoclast differentiation and maturation with particular emphasis on metabolic adaptation and therapeutic implications; Sun et al.13 comprehensively discussed osteoclast origin, differentiation, apoptosis, and coupling with osteoblasts; Zheng et al.14 highlighted the role of NFATc1 in rheumatoid arthritis (RA)-related bone destruction; and Veis offered an authoritative perspective on osteoclast function as key sculptors of bone15.