This suggests a minor role of this subset in the studied setting, although it is clear that Vδ2 T cells are able to exert antitumor effector functions.23 75 However, Vδ2 T cells of patients with melanoma showed an altered phenotype with increased levels of CD57+ cells and an impaired functionality in response to phosphoantigen stimulation compared with HD, confirming findings from previously published studies in a more comprehensive and detailed manner.76, 78. The gene discussed is B3GAT1; the disease is melanoma.