Interestingly, 14 (52%) of the FANCC-mutated RT were predicted to be germline.<h4>Conclusions</h4>Somatic and germline mutations in FANCC occur in an exceedingly small subset of clinically advanced RT but at a similar rate to other cancers, and the genomic landscape does not appear to be different from RT with wild-type FANCC. Here, FANCC is linked to cancer.