A clinical study revealed that CR at 825–853 kcal daily for 5 months lowered HbA1c in patients with T2D, resulting in T2D remission [126]; high HbA1c correlates with diminished TH1 cell polarization and glycolytic functionality via increased LPO in CD4+ T cells [36]. The gene discussed is CD4; the disease is type 2 diabetes mellitus.