HIF1A and neoplasm: In the TME, where glucose availability is scarce and conditions are highly hypoxic, tumor-associated neutrophils (TANs) dynamically switch to glutamine oxidation and FAO to provide their energetic requirements for continuous ROS production [21]; moreover, the hypoxic TME favors HIF-1α stabilization for PPP activation in neutrophils, increasing the formation of neutrophil extracellular traps (NETs) and facilitating tumor metastasis [22].