CD8A and cancer: In terms of cancer management, a ketogenic diet directly facilitates proliferation, activation, and antigen presentation of Nos2+ dendritic cells, but not other subsets, in the TME via β-hydroxybutyrate (BHB)-induced NLPR3 activation, consequently chemoattracting CD8+ T cells through CXCR3 signaling for better a ICB outcome in a mouse model of prostate cancer [100].