However, Gollapudi, R have shown that PGE2 generated by PTGS1 may inhibit the activity of 5-lipoxygenase-activating protein and 5-lipoxygenase, thereby controlling bronchoconstriction, excessive mucus secretion, and eosinophil chemotaxis caused by AA metabolites, such as leukotriene B4, potentially alleviating asthma symptoms to some extent [81]. The gene discussed is PTGS1; the disease is asthma.