PTGS2 and asthma: The PPI network, which had 31 nodes and 68 edges, was constructed using the intersection of AFB1 and asthma target genes (Fig 2) In this study, PTGS2, ADRB2, MMP9, CysLTR1, and PTGS1 were the top five targets according to degree value, representing the hub targets of AFB1-induced asthma.