Polyamines, particularly diacetylated spermine (DiAcSpm), have emerged as pivotal players in cancer biology due to their roles in cellular proliferation and oncogenic pathways, such as the phosphatase and tensin homolog-phosphatidylinositol 3-kinase-mechanistic target of rapamycin (PTEN-PI3K-Mtor), wingless/Int-1 (WNT) and rat sarcoma virus (RAS) signaling pathways [9–11]. This evidence concerns the gene PTEN and cancer.