HCN3 and cancer: Module A is composed of potentially tumour suppressor genes like PCDH9 [31,32], aging-related genes like ATP6V1G3 [33,34], genes involved in cell cycle regulation and cancer invasiveness like PKP2 [35], long noncoding RNAs like HCN3 [36], HIST2H2AA4 [37], Six3os [38], and LINC01173 related with homeostasis maintenance [39] and cancer inhibition [34,40,41], pseudogenes in this module with an undefined functions include RN7SL668P, RNA5SP68, RNU6ATAC27P, RP11-78H24.1 and RP11-696F10.1.