From January 2018 to June 2024, we reviewed 2, 177 patients diagnosed as AML and detected 155 patients (7.1%) with KIT mutation by NGS, including 110 (5.1%) patients with fusion gene RUNX1::RUNXT1 or CBFB::MYH11 and 45 patients (2.1%) without such fusion gene (Fig. 1A). The gene discussed is KIT; the disease is acute myeloid leukemia.