Whilst IgE accommodates the highest composition of FA2G2S2, it may not be relevant in this case as the clearance of terminal N-glycan sialic acids, such as FA2G2S2, on IgE depletes its functionality in effector cell degranulation and so has an anti-inflammatory effect [58]and thus a positive relationship between FA2G2S2 and COVID-19 severity would be expected[59, 60]. This evidence concerns the gene IGHE and COVID-19.