Figure 2E specifically focuses on the distribution of keratinocytes, which are the primary contributors to skin barrier function and play a key role in atopic dermatitis pathogenesis. Figure 2F presents the UMAP spatial expression of seven key genes (AKR1C2, GALE, GGH, NR4A1, P4HA1, PLA2G4B, TYMS), with the color intensity indicating the expression level from low (yellow) to high (red). This evidence concerns the gene P4HA1 and atopic eczema.