In summary, GALE-methotrexate, TYMS-methotrexate, and NR4A1-tamoxifen complexes demonstrated stable binding and favorable hydrogen bonding patterns, suggesting that methotrexate and tamoxifen interact robustly with GALE, TYMS, and NR4A1 and are potentially effective modulators in the context of atopic dermatitis. The gene discussed is NR4A1; the disease is atopic eczema.