This longitudinal follow‐up provides chronological information on the immune response to mild‐to‐moderate ZIKV infection, with an early antiviral response dominated by IFN‐γ, TNF‐α and regulated by IL‐10, followed by a peak of Th1 and then Th17‐associated cytokines that persists for up to 1 month. This evidence concerns the gene IL10 and Zika virus infectious disease.