Overall, this longitudinal cytokine monitoring provides important chronological information on the immune responses to mild‐to‐moderate ZIKV infection: (i) an early antiviral response dominated by IFN‐γ and TNF‐α, controlled by an early increase in the immune modulator IL‐10; (ii) a Th‐1 response that peaks between 1 and 2 weeks after symptom onset, followed by a Th17 response that peaks 1 week later; (iii) resolution of the Th1 response by the third week, but persistence of the Th17 response for up to a month. The gene discussed is IL10; the disease is Zika virus infectious disease.