During the acute phase of ZIKV infection, the number of specific innate and adaptive cell types temporarily increased, including intermediate CD14+CD16+ monocytes, CD69 + NK, HLA‐DR+CD38+ non‐naïve CD8+ T cells, Th1 CD4+ T cells, and Tbet+ plasma cells [51]. This evidence concerns the gene CD69 and Zika virus infectious disease.