This proposed mechanism of HSP10 binding to protein clients during folding has previously been documented in the context of bacterial HSP10 (Moparthi et al., 2014, 2016) and could be a mechanism that explains how HSP10 independently from HSP60 regulates autoimmunity and its presence in pregnancy (Corrao et al., 2010). Here, HSPE1 is linked to Autoimmunity.