ARSB and mucopolysaccharidosis type 6: Similarly, in ARSB (ENST00000264914), which is associated with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome; MIM #253200), the VUS variant p.Ter534GlnextTer50 showed a high TAILVAR score (0.995), which can be attributed to its long C-terminal extension, similar to two reported P/LP variants (with Ser and Trp at the stop codon site) within the same transcript.