To investigate whether recurrent cytogenetic aberrations correlate with aging‐related DNAm changes, we stratified the AML cohort into ten cytogenetic subgroups based on cytogenetic and molecular criteria in European LeukemiaNet recommendations [36] (e.g., CBFB::MYH11 fusion and MLLT3::KMT2A fusion) (Figure S5A). Here, KMT2A is linked to acute myeloid leukemia.