Accordingly, genetic knockdown of Mcrs1 profoundly suppressed BC cell proliferation and invasion in vitro, and in vivo experiments using an orthotopic BC model in C57BL/6 mice demonstrated significantly reduced tumor growth.<h4>Conclusion</h4>This study identifies MCRS1 as a central molecular hub that causally links aging and MetS to BC pathogenesis. Here, MCRS1 is linked to breast cancer.