Conversely, the lack of cytotoxic T-cell infiltration may be attributable to the epigenetic silencing of T helper 1 (TH1)-type chemokines like CXCL9 and CXCL10, which is known to create a ’cold’ tumor immune contexture (Nagarsheth, Wicha & Zou, 2017). The gene discussed is CXCL9; the disease is neoplasm.