Univariate logistic regression analysis identified significant associations with early DKD for: age (OR = 1.03, 95% CI [1.01–1.05], P = 0.001), hypertension history (OR = 2.78, 95% CI [1.75–4.44], P < 0.001), CRP (OR = 1.02, 95% CI [1.01–1.03], P = 0.014), IMATI (OR = 1.13, 95% CI [1.03–1.23], P = 0.008), IMATd (OR = 0.95, 95% CI [0.92–0.99], P = 0.025), SMAd (OR = 0.97, 95% CI [0.94–0.99], P = 0.036), RSFI (OR = 1.65, 95% CI [1.23–2.21], P < 0.001), RSFd (OR = 0.85, 95% CI [0.80–0.89], P < 0.001), and PATI (OR = 1.05, 95% CI [1.02–1.08], P = 0.001). The gene discussed is CRP; the disease is diabetic kidney disease.