Their analysis identified 49 overlapping genes between chemical targets and chronic kidney disease (CKD)-related pathways, with enrichment of tumor necrosis factor (TNF), interleukin-17 (IL-17), mitogen-activated protein kinase (MAPK), and NOD-like receptor signaling, and molecular docking confirmed strong binding to MAPK3 and TNF. This evidence concerns the gene TNF and chronic kidney disease.