CCL2 and neoplasm: Monocyte chemoattractant protein-1 (CCL2/MCP-1), CXCL1, CXCL8, and other chemokines elevated during systemic inflammation recruit myeloid-derived suppressor cells (MDSCs), macrophages, and neutrophils to the prostate microenvironment, collectively promoting tumor growth and immune evasion [59].