POMC and panhypopituitarism: IgG4-related hypophysitis reflects pituitary gland involvement which may present as an isolated hormone deficiency or panhypopituitarism and thus, basal pituitary hormonal testing is needed such as measurements of ACTH, cortisol, TSH, free T4, LH, FSH, prolactin, GH, and IGF-1 alongside ACTH stimulation or insulin tolerance test as part of dynamic testing34.